Formation and elimination of sulphamethoxazole hydroxylamine after oral administration of sulphamethoxazole.

-ormation and elimination of sulphamethoxazole hydroxylamine after oral administration of sulphamethoxazole

Esch. coli endocarditis successfully treated with oral trimethoprim and sulphamethoxazole.

A 42-year-old patient was successfully treated for subacute bacterial endocarditis due to Esch. coli with oral trimethoprim and sulphamethoxazole. The treatment lasted nine months and was continued through a period of cholestatic jaundice superimposed on hepatic damage due to subacute bacterial endocarditis. There were no toxic effects attributable to the two antibacterials despite their prolon...

Short-term treatment of gonorrhoea with intramuscular and oral forms of trimethoprim-sulphamethoxazole.

Fifty-nine male patients and 41 female patients with uncomplicated gonorrhoea were treated with an intramuscular dose of 1600 mg sulphamethoxazole plus 320 mg trimethoprim followed by an oral dose of 2400 mg sulphamethoxazole plus 480 mg trimethoprim 12 hours later. Forty-nine out of 52 male patients and 37 out of 38 female patients who were re-examined were cured. One of the men probably had a...

Simulataneous Analysis of Trimethoprim and Sulphamethoxazole Drug Combinations in Dosage Forms by High Performance Liquid Chromatography

A sensitive high performance liquid chromathography (HPLC) analytical procedure was developed for the quantitive determination of trimethoprim (TM* and sulphamethoxazole (SM) in commercial dosage forms. C18 analytical column (stainless steel, 25 cm * 4.6 mm i.d.) was packed with 5-*m particles of the reversed phase material and used for assays. Mobile phase containing 0.025 M sodium phosphate...

In-vitro activity of atovaquone, sulphamethoxazole and dapsone alone and combined with inhibitors of dihydrofolate reductase and macrolides against Pneumocystis carinii.

The anti-Pneumocystis carinii activity of atovaquone, dapsone and sulphamethoxazole alone and combined with dihydrofolate reductase (DHFR) inhibitors and macrolides was investigated against five clinical isolates of P. carinii. The susceptibility tests were performed by inoculation of the organisms on to cell monolayer and parasite count after 72 h incubation at 37 degrees C. Culture plates wer...